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ICD-10-CM Code D53.1
Other megaloblastic anemias, not elsewhere classified

Billable Code
Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis.
| ICD-10 from 2011 - 2016

D53.1 is a billable ICD code used to specify a diagnosis of other megaloblastic anemias, not elsewhere classified. A 'billable code' is detailed enough to be used to specify a medical diagnosis.

The ICD code D531 is used to code Megaloblastic anemia

Megaloblastic anemia (or megaloblastic anaemia) is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis during red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M) stage. This leads to continuing cell growth without division, which presents as macrocytosis. Megaloblastic anemia has a rather slow onset, especially when compared to that of other anemias. The defect in red cell DNA synthesis is most often due to hypovitaminosis, specifically a deficiency of vitamin B12 and/or folic acid. Vitamin B12 deficiency alone will not cause the syndrome in the presence of sufficient folate, as the mechanism is loss of B12 dependent folate recycling, followed by folate-deficiency loss of nucleic acid synthesis (specifically thymine), leading to defects in DNA synthesis. Folic acid supplementation in the absence of vitamin B12 prevents this type of anemia (although other vitamin B12-specific pathologies may be present). Loss of micronutrients may also be a cause. Copper deficiency resulting from an excess of zinc from unusually high oral consumption of zinc-containing denture-fixation creams has been found to be a cause.

Specialty: Hematology
MeSH Code: D000749
ICD 9 Code: 281

Peripheral blood smear showing hypersegmented neutrophils, characteristic of megaloblastic anemia.

Source: Wikipedia

Coding Notes for D53.1 Info for medical coders on how to properly use this ICD-10 code

Inclusion Terms:
Inclusion Terms
Inclusion Terms are a list of concepts for which a specific code is used. The list of Inclusion Terms is useful for determining the correct code in some cases, but the list is not necessarily exhaustive.
Megaloblastic anemia NOS
Code Type-1 Excludes:
Type-1 Excludes
Type-1 Excludes mean the conditions excluded are mutually exclusive and should never be coded together. Excludes 1 means "do not code here."
Di Guglielmo's disease - instead, use code C94.0

MS-DRG Mapping

  • DRG Group #811-812 - Red blood cell disorders with MCC.
  • DRG Group #811-812 - Red blood cell disorders without MCC.

Related Concepts SNOMET-CT

  • Acute megaloblastic anemia secondary to total parenteral nutrition (disorder)

Coding Advice SNOMET-CT

  • Possible requirement for additional code to fully describe disease or condition

ICD-10-CM Alphabetical Index References for 'D53.1 - Other megaloblastic anemias, not elsewhere classified'

The ICD-10-CM Alphabetical Index links the below-listed medical terms to the ICD code D53.1. Click on any term below to browse the alphabetical index.


Other specified megaloblastic anemias not elsewhere classified (exact match)

This is the official exact match mapping between ICD9 and ICD10, as provided by the General Equivalency mapping crosswalk. This means that in all cases where the ICD9 code 281.3 was previously used, D53.1 is the appropriate modern ICD10 code.

Parent Code: D53 - Other nutritional anemias

** This Document Provided By ICD.Codes **
Source: http://icd.codes/icd10cm/D531