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ICD-10-CM Code E16.4
Increased secretion of gastrin

Billable Code
Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis.
| ICD-10 from 2011 - 2016

E16.4 is a billable ICD code used to specify a diagnosis of increased secretion of gastrin. A 'billable code' is detailed enough to be used to specify a medical diagnosis.

The ICD code E164 is used to code Zollinger-Ellison syndrome

Zollinger–Ellison Syndrome (ZES) is caused by a non–beta islet cell (islet of Langerhans), gastrin-secreting tumor of the pancreas that stimulates the acid-secreting cells of the stomach (parietal cells) to maximal activity, with consequent gastrointestinal mucosal ulceration. ZES may occur sporadically or as part of an autosomal dominant familial syndrome called multiple endocrine neoplasia type 1 (MEN 1). The primary tumor is usually located in the pancreas, duodenum or abdominal lymph nodes, but ectopic locations have also been described (e.g., heart, ovary, gallbladder, liver, kidney).

Specialty: Endocrinology
MeSH Code: D015043
ICD 9 Code: 251.5

Endoscopy image of multiple small ulcers in the distal duodenum in a patient with Zollinger–Ellison syndrome

Source: Wikipedia

Coding Notes for E16.4 Info for medical coders on how to properly use this ICD-10 code

Inclusion Terms:
Inclusion Terms
Inclusion Terms are a list of concepts for which a specific code is used. The list of Inclusion Terms is useful for determining the correct code in some cases, but the list is not necessarily exhaustive.
Hyperplasia of pancreatic endocrine cells with gastrin excess
Zollinger-Ellison syndrome

MS-DRG Mapping

  • DRG Group #380-384 - Complicated peptic ulcer with MCC.
  • DRG Group #380-384 - Complicated peptic ulcer with CC.
  • DRG Group #380-384 - Complicated peptic ulcer without CC or MCC.
  • DRG Group #380-384 - Uncomplicated peptic ulcer with MCC.
  • DRG Group #380-384 - Uncomplicated peptic ulcer without MCC.

Related Concepts SNOMET-CT

  • Hyperplasia of islet alpha cells with gastrin excess (disorder)
  • Increased gastrin secretion (disorder)

ICD-10-CM Alphabetical Index References for 'E16.4 - Increased secretion of gastrin'

The ICD-10-CM Alphabetical Index links the below-listed medical terms to the ICD code E16.4. Click on any term below to browse the alphabetical index.

Zollinger-Ellison syndrome (E16.4)
Hypergastrinemia (E16.4)
Ellison-Zollinger syndrome (E16.4)


Abnormality of secretion of gastrin (exact match)

This is the official exact match mapping between ICD9 and ICD10, as provided by the General Equivalency mapping crosswalk. This means that in all cases where the ICD9 code 251.5 was previously used, E16.4 is the appropriate modern ICD10 code.

Parent Code: E16 - Other disorders of pancreatic internal secretion

** This Document Provided By ICD.Codes **
Source: http://icd.codes/icd10cm/E164