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ICD-10-CM Code E88.81
Metabolic syndrome

BILLABLE
Billable Code
Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis.
| ICD-10 from 2011 - 2016

E88.81 is a billable ICD code used to specify a diagnosis of metabolic syndrome. A 'billable code' is detailed enough to be used to specify a medical diagnosis.


The ICD code E888 is used to code Trimethylaminuria

Trimethylaminuria (TMAU), as defined by the KIM consortium of endocrinology disorders as fish odor syndrome or fish malodor syndrome, is a rare metabolic disorder that causes a defect in the normal production of an enzyme named flavin-containing monooxygenase 3 (FMO3). When FMO3 is not working correctly or if not enough enzyme is produced, the body loses the ability to properly convert trimethylamine (TMA) from precursor compounds in food digestion into trimethylamine oxide (TMAO), through a process called N-oxygenation. Trimethylamine then builds up and is released in the person's sweat, urine, and breath, giving off a strong fishy odor or strong body odor. A variant of TMAU (secondary TMAU or TMAU2) exists where there is no genetic cause, yet excessive TMA is secreted, possibly due to intestinal dysbiosis, altered metabolism, or hormonal reasons.

Specialty: Endocrinology
ICD 9 Code: 270.8

Trimethylamine

Source: Wikipedia

Coding Notes for E88.81 Info for medical coders on how to properly use this ICD-10 code

Inclusion Terms:
Inclusion Terms
Inclusion Terms are a list of concepts for which a specific code is used. The list of Inclusion Terms is useful for determining the correct code in some cases, but the list is not necessarily exhaustive.
Dysmetabolic syndrome X
Additional Code Note:
Use Additional Code
Use Additional Code note means a second code must be used in conjunction with this code. Codes with this note are Etiology codes and must be followed by a Manifestation code or codes.
Codes for associated manifestations, such as:
Obesity See code E66.-

MS-DRG Mapping

  • DRG Group #642 - Inborn and other disorders of metabolism.

Related Concepts SNOMET-CT

  • Insulin resistance in diabetes (disorder)

Coding Advice SNOMET-CT

  • Consider additional code to identify specific condition or disease
  • Possible requirement for causative disease code

ICD-10-CM Alphabetical Index References for 'E88.81 - Metabolic syndrome'

The ICD-10-CM Alphabetical Index links the below-listed medical terms to the ICD code E88.81. Click on any term below to browse the alphabetical index.

Metabolic syndrome (E88.81)
Dysmetabolic syndrome X (E88.81)

Equivalent ICD-9 Code GENERAL EQUIVALENCE MAPPINGS (GEM)

Dysmetabolic syndrome X (exact match)

This is the official exact match mapping between ICD9 and ICD10, as provided by the General Equivalency mapping crosswalk. This means that in all cases where the ICD9 code 277.7 was previously used, E88.81 is the appropriate modern ICD10 code.


Parent Code: E88.8 - Other specified metabolic disorders

** This Document Provided By ICD.Codes **
Source: http://icd.codes/icd10cm/E8881