ICD-10-CM Code R74.0
Nonspecific elevation of levels of transaminase and lactic acid dehydrogenase [LDH]

In medicine, the presence of elevated transaminases, commonly the transaminases alanine transaminase (ALT) and aspartate transaminase (AST), may be an indicator of liver damage. Other terms employed include transaminasemia and transaminitis, although some sources consider the latter pathologically meaningless. Normal ranges for both ALT and AST are 8-40 U/L with mild transaminesemia noted to the upward numerical limit of 250 U/L. Drug-induced increases such as that found with the use of anti-tuberculosis agents such as isoniazid are limited typically to below 100 U/L for either ALT or AST. Cirrhosis of the liver or fulminant liver failure secondary to hepatitis commonly reach values for both ALT and AST in the >1000+ U/L range. Elevated transaminases that persist less than six months are termed 'acute' in nature, and those values that persist for six months or more are termed 'chronic' in nature.