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ICD-10-CM Code G21.0
Malignant neuroleptic syndrome

BILLABLE
Billable Code
Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis.
| ICD-10 from 2011 - 2016

G21.0 is a billable ICD code used to specify a diagnosis of malignant neuroleptic syndrome. A 'billable code' is detailed enough to be used to specify a medical diagnosis.


The ICD code G210 is used to code Neuroleptic malignant syndrome

Neuroleptic malignant syndrome (NMS) is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. NMS typically consists of muscle rigidity, fever, autonomic instability, and cognitive changes such as delirium, and is associated with elevated plasma creatine phosphokinase. The incidence of neuroleptic malignant syndrome has decreased since it was first described, due to changes in prescribing habits, but NMS is still a potential danger to patients being treated with antipsychotic medication. Because of the unpredictability of NMS, treatment may vary substantially but is generally based on supportive care and removal of the offending antipsychotic drug.

Specialty: Critical Care Medicine, Neurology
MeSH Code: D009459
ICD 9 Code: 333.92

Haloperidol, a known cause of NMS

Source: Wikipedia

Coding Notes for G21.0 Info for medical coders on how to properly use this ICD-10 code

Additional Code Note:
Use Additional Code
Use Additional Code note means a second code must be used in conjunction with this code. Codes with this note are Etiology codes and must be followed by a Manifestation code or codes.
Code for adverse effect, if applicable, to identify drug (T43.3X5, T43.4X5, T43.505, T43.595) See code T43.3X
Code Type-1 Excludes:
Type-1 Excludes
Type-1 Excludes mean the conditions excluded are mutually exclusive and should never be coded together. Excludes 1 means "do not code here."
Neuroleptic induced parkinsonism - instead, use code G21.11

MS-DRG Mapping

  • DRG Group #091-093 - Other disorders of nervous system with MCC.
  • DRG Group #091-093 - Other disorders of nervous system with CC.
  • DRG Group #091-093 - Other disorders of nervous system without CC or MCC.

Coding Advice SNOMET-CT

  • Possible requirement for an external cause code

ICD-10-CM Alphabetical Index References for 'G21.0 - Malignant neuroleptic syndrome'

The ICD-10-CM Alphabetical Index links the below-listed medical terms to the ICD code G21.0. Click on any term below to browse the alphabetical index.

Equivalent ICD-9 Code GENERAL EQUIVALENCE MAPPINGS (GEM)

Neuroleptic malignant syndrome (exact match)

This is the official exact match mapping between ICD9 and ICD10, as provided by the General Equivalency mapping crosswalk. This means that in all cases where the ICD9 code 333.92 was previously used, G21.0 is the appropriate modern ICD10 code.


Parent Code: G21 - Secondary parkinsonism

** This Document Provided By ICD.Codes **
Source: http://icd.codes/icd10cm/G210