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ICD-10-CM Code E21.3
Hyperparathyroidism, unspecified

Billable Code
Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis.
| ICD-10 from 2011 - 2016

E21.3 is a billable ICD code used to specify a diagnosis of hyperparathyroidism, unspecified. A 'billable code' is detailed enough to be used to specify a medical diagnosis.

The ICD code E21 is used to code Hyperparathyroidism

Hyperparathyroidism is inappropriate overactivity of the parathyroid glands resulting in parathyroid hormone (PTH) levels in the blood plasma which are in excess of what a normally functioning plasma ionized calcium regulator (or homeostat, or negative feedback mechanism) would produce. Normal parathyroid glands measure the ionized calcium (Ca2+) concentration in the blood plasma and secrete parathyroid hormone accordingly: if the ionized calcium rises above normal the secretion of PTH is decreased, whereas when the Ca2+ level falls, parathyroid hormone secretion is increased. In primary hyperparathyroidism, the release of parathyroid hormone into the blood is no longer determined by the current plasma Ca2+ level, but is persistently above what is appropriate. This may be due to a parathyroid adenoma which secretes PTH independently of changes in the plasma ionized calcium concentration. This leads to hypercalcemia (abnormally high plasma calcium levels). Secondary hyperparathyroidism occurs if the plasma ionized calcium level does not respond to changes in PTH secretion from normal glands, and therefore remains abnormally low (hypocalcemia). The normal glands respond by secreting parathyroid hormone at a persistently high rate. This typically occurs when the 1,25 dihydroxyvitamin D3 levels in the blood are low or absent. 1,25 Dihydroxyvitamin D3 (or calcitriol) is the active hormone which determines the quantity of calcium absorbed from the duodenum. Its absence therefore causes hypocalcemia, to which the parathyroid glands respond by secreting large quantities of PTH into the blood (i.e. "secondary hyperparathyroidism"). A lack of 1,25 dihydroxyvitamin D3 can result from a deficient dietary intake of vitamin D, or from a lack of exposure of the skin to sunlight, so that the body cannot make its own vitamin D from cholesterol. The resulting hypovitaminosis D is usually due to a partial combination of both factors. Vitamin D is converted to vitamin D3 (or cholecalciferol) by the liver, from where it is transported via the circulation to the kidneys where it is converted into the active hormone, 1,25 dihydroxyvitamin D3. Thus a third cause of secondary hyperparathyroidism is chronic kidney disease. Here the ability to manufacture 1,25 dihydroxyvitamin D3 is compromised, resulting in hypocalcemia. In both primary and secondary hyperparathyroidism, the high plasma PTH levels erode the skeleton, predisposing it to fractures and bone deformities, necessitating interventions to reverse the high PTH levels in the blood.

Specialty: Endocrinology
MeSH Code: D006961
ICD 9 Code: 252.0

Thyroid and parathyroid.

Source: Wikipedia

MS-DRG Mapping

  • DRG Group #643-645 - Endocrine disorders with MCC.
  • DRG Group #643-645 - Endocrine disorders with CC.
  • DRG Group #643-645 - Endocrine disorders without CC or MCC.

Related Concepts SNOMET-CT

  • Calcifying panniculitis due to hyperparathyroidism (disorder)

ICD-10-CM Alphabetical Index References for 'E21.3 - Hyperparathyroidism, unspecified'

The ICD-10-CM Alphabetical Index links the below-listed medical terms to the ICD code E21.3. Click on any term below to browse the alphabetical index.


Hyperparathyroidism, unspecified (exact match)

This is the official exact match mapping between ICD9 and ICD10, as provided by the General Equivalency mapping crosswalk. This means that in all cases where the ICD9 code 252.00 was previously used, E21.3 is the appropriate modern ICD10 code.

Parent Code: E21 - Hyperparathyroidism and other disorders of parathyroid gland

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Source: http://icd.codes/icd10cm/E213